Endocrine Abstracts

Objective: To evaluate the optimal parameters and the cut-off points of captopril challenge test (CCT) in the diagnosis of primary aldosteronism (PA) using chemiluminescence immunoassays (CLIA).Methods: Patients with clinically suspected PA who admitted to our hospital between July 2021 and December 2021 were recruited. Both supine and upright aldosterone to renin ratio (ARR) were calculated in all the participants and 21 healthy volunteers. CCT was perf...

Type 1 diabetes mellitus (T1DM) not only is congenital disease that known as insulin-dependent diabetes, often occurs in children and adolescents. Recent advances in quantitative proteomics including fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for underst...

Background: Various social determinant of health (SDOH) metrics and indices are utilized to evaluate access to cancer care and to explain disparities in outcome in pancreatic neuroendocrine tumors (PNETs). Little prior work has compared the validity of various geographic metrics. Therefore we aimed to examine different geographic metrics validity (from smallest to largest: census block group< census tract< zip code< county) utilizing single institutional data in a ...

Background: Tumor size and lymph node involvement (stage) have been utilized to prognosticate pancreatic neuroendocrine tumors (PNETs) but the influence of race and social vulnerability on these factors remains unexplored. Therefore we sought to explore this in a racially and socioeconomically diverse cohort.Methods: We reviewed records of all patients who underwent surgical resection for PNETs from 2006-2022 at a single NCI-designated cancer center in t...

Background: Cardiovascular disease (CVD) is a serious complication of diabetes mellitus (DM) and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetes and CVD.Objective: To assessed the alteration of DNA methylation in patients with/without diabetes but developed CVD in a cohort study of Chinese patients.Methods: 40 patients ...

Thyroid hormone (TH) actions and metabolism are intracellular events that require the transport of TH across the plasma membrane. This process is facilitated by TH transporters of which the monocarboxylate transporter 8 (MCT8), encoded by the Slc16a2 gene, has been most intensively analyzed. In humans, inactivating mutations in the X-linked MCT8 gene are associated with a severe form of psychomotor retardation in combination with abnormal serum TH parameters. The clin...

Introduction: Premature ovarian insufficiency (POI) affects approximately 1% of females. In POI, hormone replacement manages symptoms and reduces the risk of bone mineral density (BMD) loss as oestrogen acts to enhance bone deposition in bone remodelling. Oestrogen may be given either as synthetic oestrogen (ethinylestradiol) as in most combined oral contraceptives (COCP), or as physiological oestrogen (oestradiol) as in hormone replacement therapy (HRT preparations) and a sel...

A 49-year-old man who has diabetes mellitus and alcoholic cirrhosis presented to the emergency department due to left upper quadrant abdominal pain and left back soreness for three days. He received sclerotherapy and endoscopic band ligation twice for gastric varices few months prior to admission. On physical examination, he had rebound tenderness at left upper abdomen. The computed tomography (CT) of abdomen revealed diffusely enlarged left adrenal gland with rim-enhanced mul...

62-year-old woman was an employee of catering service. She had progressive limb weakness, easpecially proximal part since May, 2015, with diurnal change. She had difficulties in lifting arms, holding plates steady, and knee buckling while walking, which made her quit the job. Generalized myasthenia gravis (MG) was confirmed by positive acetylcholine receptor antibody (12.8 nmol/l) and marked decremental changes in repetitive stimulation test in November, 2015. Her limb weaknes...

Exposure to soy isoflavones (ISO), abundant in soy protein infant formula, during early postnatal life has benefits to bone health in female mice. Moreover, exposure during the first 10 or 21 days of life has been shown to interfere with structural development of female reproductive organs and results in heavier body weight. The study objective was to compare if shorter exposure to ISO, during the first 5 vs 10 days of life, results in lesser adverse effects on ovarian and ute...